Defiant could refer to:

• Defiant history, the history of such vessels
  • HMS Defiant, The British Royal Navy ship
  • ISS Defiant, a Terran Rebellion starship from the 24th century mirror universe
  • USS Defiant (2370), registry NX-74205, lead ship of the class, the first Defiant-class starship to bear the name
  • USS Defiant (2375), the second Defiant-class starship to bear the name (formerly the USS Sao Paulo)
  • USS Defiant (NCC-1764), a Constitution-class starship
• Defiant-class escort, a Federation starship type

Real world

• "Defiant", a Season Three episode of Star Trek: Deep Space Nine
• USS Defiant (alternate reality), an alternate universe ship mentioned only in the script of Star Trek.

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