2133 — memory alpha

Events

A Klingon vessel emerges from the Delphic Expanse with its crew being anatomically inverted, but still alive. (ENT: "The Expanse")

According to the first draft of TOS: "Where No Man Has Gone Before", the SS Valiant (then described as the USS Valiant) was launched this year.
According to the Star Trek Chronology, it was in this year, that Bajoran religious leader Kai Taluno, while traveling in the Denorios belt, experiences a serious malfunction of his spacecraft and is stranded for several days. Taluno reports having experienced a vision in which "the heavens opened up," nearly swallowing his ship. Taluno's experience is one of many recorded incidents that lead to the discovery in 2369 of the Bajoran wormhole, which the Bajorans identify as the Celestial Temple of the Prophets. DS9: "Emissary" merely places this event sometime during the 22nd century.
According to a scripted but ultimately omitted scene from an early draft of "Home", where Jonathan Archer was to have visited his father's grave on Earth. According to Henry Archer's grave marker, he was supposeded to have died in this year. (ENT Season 4 Blu-ray special features)